Cytochroma Announces Positive Comparative Data on CTA018 in Chronic Kidney Disease Model:
MARKHAM, Ontario, Nov 06, 2009:
Cytochroma announced positive comparative data on a novel vitamin D analog, CTA018, at the 2009 Annual Meeting of the American Society of Nephrology (ASN) in Philadelphia. In preclinical models, CTA018 has demonstrated advantages over two marketed vitamin D hormone replacement therapies, calcitriol and paricalcitol (Zemplar(R)), the latter currently being the most widely used therapy for secondary hyperparathyroidism (SHPT) in the United States (U.S.). These data were presented in a poster presentation entitled "The Metabolic Profile of CTA018 Confers Therapeutic and Safety Advantages over Current Therapies in an Adenine-Induced Model of Chronic Kidney Disease (CKD)."

CTA018 is the first compound in a new class of vitamin D hormone analogs having a novel dual mechanism of action. CTA018 is designed to be a strong activator of the vitamin D signaling pathway as well as a potent inhibitor of CYP24, the intracellular cytochrome P450 enzyme responsible for inactivation of vitamin D hormones. Based on its mechanism of action, CTA018 is expected to be safer and more effective in treating SHPT than currently available therapies. CTA018 was designed by Professor Gary H. Posner, Ph.D. and is protected under patents and patent applications exclusively licensed to Cytochroma from the Johns Hopkins University.

Cytochroma is a clinical stage specialty pharmaceutical company focused on developing and commercializing proprietary products to treat and prevent the clinical consequences of vitamin D insufficiency and SHPT associated with CKD. The Company's vitamin D-based therapeutics are designed to safely and effectively treat patients with Stage 3, 4 or 5 CKD. Cytochroma has three lead product candidates in development for CKD patients: CTA018 Injection and CTAP201 Injection are being developed for the treatment of SHPT, while CTAP101 Capsules are being developed for the treatment of vitamin D insufficiency. In addition, Cytochroma is developing novel therapies to treat hyperphosphatemia in these same patients.

Source: MarketWatch Press Release, Nov. 6, 2009

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